| GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson?s disease |
| Jiao, LJ; Su, LY; Liu, QJ; Luo, RC; Qiao, XH; Xie, T; Yang, LX; Chen, C; Yao, YG
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| 2022
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| 发表期刊 | FREE RADICAL BIOLOGY AND MEDICINE
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| ISSN | 0891-5849
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| 卷号 | 189页码:111-121 |
| 摘要 | The S-nitrosoglutathione reductase (GSNOR) is a key denitrosating enzyme that regulates protein S-nitrosation, a process which has been found to be involved in the pathogenesis of Parkinson's disease (PD). However, the physiological function of GSNOR in PD remains unknown. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, we found that GSNOR expression was significantly increased and accompanied by autophagy mediated by MPTP-induced cyclin dependent kinase 5 (CDK5), behavioral dyskinesias and dopaminergic neuron loss. Whereas, knockout of GSNOR, or treatment with the GSNOR inhibitor N6022, alleviated MPTP-induced PD-like pathology and neurotoxicity. Mechanistically, deficiency of GSNOR inhibited MPTP-induced CDK5 kinase activity and CDK5-mediated autophagy by increasing S-nitrosation of CDK5 at Cys83. Our study indicated that GSNOR is a key regulator of CDK5 S-nitrosation and is actively involved in CDK5-mediated autophagy induced by MPTP. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13473
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| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
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推荐引用方式
GB/T 7714 |
Jiao, LJ,Su, LY,Liu, QJ,et al. GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson?s disease[J]. FREE RADICAL BIOLOGY AND MEDICINE,2022,189:111-121.
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| APA |
Jiao, LJ.,Su, LY.,Liu, QJ.,Luo, RC.,Qiao, XH.,...&Yao, YG.(2022).GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson?s disease.FREE RADICAL BIOLOGY AND MEDICINE,189,111-121.
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| MLA |
Jiao, LJ,et al."GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson?s disease".FREE RADICAL BIOLOGY AND MEDICINE 189(2022):111-121.
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