Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing

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	Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing
	Zhang, DF; Li, HL; Zheng, QZ; Bi, R; Xu, M; Wang, D; Zhu, GP; Li, YY; Yao, YG
	2021
发表期刊	CLINICAL GENETICS
ISSN	0009-9163
卷号	99 期号:6 页码:802-811
摘要	Previous genotyping-based assays have identified non-coding variants of several interleukins (ILs) being associated with genetic susceptibility to leprosy. However, understanding of the involvement of coding variants within all IL family genes in leprosy was still limited. To obtain the full mutation spectrum of all ILs in leprosy, we performed a targeted deep sequencing of coding regions of 58 ILs genes in 798 leprosy patients (age 56.2 +/- 14.4; female 31.5%) and 990 healthy controls (age 38.1 +/- 14.0; female 44.3%) from Yunnan, Southwest China. mRNA expression alterations of ILs in leprosy skin lesions or in response to M. leprae treatment were estimated by using publicly available expression datasets. Two coding variants in IL27 (rs17855750, p.S59A, p = 4.02 x 10(-8), odds ratio [OR] = 1.748) and IL1RN (rs45507693, p.A106T, p = 1.45 x 10(-5), OR = 3.629) were significantly associated with leprosy risk. mRNA levels of IL27 and IL1RN were upregulated in whole blood cells after M. leprae stimulation. These data showed that IL27 and IL1RN are leprosy risk genes. Further functional study is required for characterizing the exact role of ILs in leprosy.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13485
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）昆明动物研究所
推荐引用方式 GB/T 7714	Zhang, DF,Li, HL,Zheng, QZ,et al. Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing[J]. CLINICAL GENETICS,2021,99(6):802-811.
APA	Zhang, DF.,Li, HL.,Zheng, QZ.,Bi, R.,Xu, M.,...&Yao, YG.(2021).Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing.CLINICAL GENETICS,99(6),802-811.
MLA	Zhang, DF,et al."Mapping leprosy-associated coding variants of interleukin genes by targeted sequencing".CLINICAL GENETICS 99.6(2021):802-811.

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