| Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr |
| Tang, XH; Luo, RC; Ye, MS; Tang, HY; Ma, YL; Chen, YN; Wang, XM; Lu, QY; Liu, S; Li, XN; Yan, Y; Yang, J; Ran, XQ; Fang, X; Zhou, Y; Yao, YG ; Di, YT; Hao, XJ
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| 2021
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| 发表期刊 | ORGANIC LETTERS
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| ISSN | 1523-7060
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| 卷号 | 23期号:2页码:262-267 |
| 摘要 | Harpertrioate A (1), an A, B,D-seco-limonoid with a rearranged ring B incorporating exocyclic C-30, was isolated from the EtOAc extract of Harrisonia perforata twigs. Its structure, including absolute configurations, was determined on the basis of spectroscopic data and X-ray crystallography. This compound exhibited biological activities against Alzheimer's disease by reducing A beta 42 and A beta 40 production and shifting APP processing toward nonamyloidogenic pathway. The effect of 1 on the A beta production was comparable to that of gemfibrozil. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13493
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| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
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推荐引用方式
GB/T 7714 |
Tang, XH,Luo, RC,Ye, MS,et al. Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr[J]. ORGANIC LETTERS,2021,23(2):262-267.
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| APA |
Tang, XH.,Luo, RC.,Ye, MS.,Tang, HY.,Ma, YL.,...&Hao, XJ.(2021).Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr.ORGANIC LETTERS,23(2),262-267.
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| MLA |
Tang, XH,et al."Harpertrioate A, an A,B,D-seco-Limonoid with Promising Biological Activity against Alzheimer's Disease from Twigs of Harrisonia perforata (Blanco) Merr".ORGANIC LETTERS 23.2(2021):262-267.
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