| Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy |
| Yan, Y; Ran, XQ; Wang, D ; Zhang, X; Peng, MY; Yan, XY; Tang, L; Liang, H; Qin, XJ; Di, YT; Luo, RC; Hao, XJ; Yao, YG
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| 2023
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| 发表期刊 | ORGANIC & BIOMOLECULAR CHEMISTRY
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| ISSN | 1477-0520
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| 卷号 | 21期号:3页码:514-519 |
| 摘要 | Munronin V (1), isolated from Munronia henryi Harms, is the first example, to the best of our knowledge, of an unprecedented 7/7/6 tricarbocyclic framework featuring an unusual A,B-seco-limonoid ring. The structures of munronin V were established from extensive spectroscopic and electronic circular dichroism (ECD) analyses. The novel A,B-seco with two seven-membered lactones was formed as a result of Baeyer-Villiger oxidation. Compound 1 activated autophagy and inhibited Tau pathology as revealed by flow cytometric analyses, confocal imaging analysis and western blotting, and this effect was mediated by transcription factor EB (TFEB). These findings suggested that 1 might have potential as a compound for combating Alzheimer's disease. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13495
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| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
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推荐引用方式
GB/T 7714 |
Yan, Y,Ran, XQ,Wang, D,et al. Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2023,21(3):514-519.
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| APA |
Yan, Y.,Ran, XQ.,Wang, D.,Zhang, X.,Peng, MY.,...&Yao, YG.(2023).Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy.ORGANIC & BIOMOLECULAR CHEMISTRY,21(3),514-519.
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| MLA |
Yan, Y,et al."Munronin V with 7/7/6 tricarbocyclic framework from Munronia henryi harms inhibits tau pathology by activating autophagy".ORGANIC & BIOMOLECULAR CHEMISTRY 21.3(2023):514-519.
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