Abnormal neurobehavior in fish early life stages after exposure to cyanobacterial exudates

	Abnormal neurobehavior in fish early life stages after exposure to cyanobacterial exudates
	Cai, WW; MacIsaac, HJ; Xu, RB; Zhang, JL; Pan, XF; Zhang, YW; Yang, JX; Dixon, B; Li, JJ; Zi, YY; Chang, XX
	2022
发表期刊	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN	0147-6513
卷号	245
摘要	Cyanobacterial harmful algal blooms (cHABs) pose a risk to exposed aquatic and terrestrial species. Numerous studies have addressed effects of single toxins while much less attention has been devoted to mixtures of cHAB metabolites that are continually released by living cyanobacteria. Neuro-impairment associated with cHABs has been reported in fish, though the mechanism remains unclear. Here we exposed embryos of Sinocyclocheilus grahami, an endangered fish, to Microcystis aeruginosa exudates (MaE) to evaluate neurotoxicity and the toxicity mechanism(s). We found that MaE affected embryonic development by increasing malformation and mortality rates and decreasing the fertilization rate. MaE also inhibited fish neurobehavior including touch response, social frequency, swimming distance, and aggravated light-stimulation response. Neurobehavior suppression resulted from a decrease in excitatory neurotransmitters acetylcholine and dopamine, even though receptors increased. MaE also affected gene and protein expression of neurotransmitters, synthetic and/or degrading enzymes, and receptors. Our findings shed light on specific mechanisms by which MaE induces neurotoxicity in early life stages in fish and contributes to improvement of the conservation strategy for this species.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13512
专题	科研部门_系统进化与生物地理学（杨君兴）
推荐引用方式 GB/T 7714	Cai, WW,MacIsaac, HJ,Xu, RB,et al. Abnormal neurobehavior in fish early life stages after exposure to cyanobacterial exudates[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2022,245.
APA	Cai, WW.,MacIsaac, HJ.,Xu, RB.,Zhang, JL.,Pan, XF.,...&Chang, XX.(2022).Abnormal neurobehavior in fish early life stages after exposure to cyanobacterial exudates.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,245.
MLA	Cai, WW,et al."Abnormal neurobehavior in fish early life stages after exposure to cyanobacterial exudates".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 245(2022).

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