High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice

	High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice
	Hou, XF; Zhao, YB; Yang, YX; Ma, C; Li, M; Li, X; Ma, GR; Zhu, LS; Xu, L; Zhou, QX
	2022
发表期刊	BRAIN SCIENCES
卷号	12 期号:12
摘要	An obvious reason for substance uses disorders (SUDs) is drug craving and seeking behavior induced by conditioned context, which is an abnormal solid context memory. The relationship between susceptibility to SUD and learning ability remains unclear in humans and animal models. In this study, we found that susceptibility to morphine use disorder (MUD) was negatively correlated with learning ability in conditioned place preference (CPP) in C57 mice. By using behavioral tests, we identified the FVB mouse as learning impaired. In addition, we discovered that learning-relevant proteins, such as the glutamate receptor subunits GluA1, NR1, and NR2A, were decreased in FVB mice. Finally, we assessed the context learning ability of FVB mice using the CPP test and priming. We found that FVB mice had lower learning performance with respect to normal memory but higher performance of morphine-reinstatement memory. Compared to C57 mice, FVB mice are highly sensitive to MUDs. Our results suggest that SUD susceptibility is predicted by impaired learning ability in mice; therefore, learning ability can play a simple and practical role in identifying high-risk SUD groups.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13517
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Hou, XF,Zhao, YB,Yang, YX,et al. High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice[J]. BRAIN SCIENCES,2022,12(12).
APA	Hou, XF.,Zhao, YB.,Yang, YX.,Ma, C.,Li, M.,...&Zhou, QX.(2022).High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice.BRAIN SCIENCES,12(12).
MLA	Hou, XF,et al."High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice".BRAIN SCIENCES 12.12(2022).

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