| Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines |
| Cao, P; Chen, CM; Liu, A; Shan, QH; Zhu, X; Jia, CH; Peng, XQ; Zhang, MJ; Farzinpour, Z; Zhou, WJ; Wang, HT; Zhou, JN; Song, XY; Wang, LC; Tao, WJ; Zheng, CJ; Zhang, Y ; Ding, YQ; Jin, Y; Xu, L; Zhang, Z
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| 2021
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| 发表期刊 | NEURON
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| ISSN | 0896-6273
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| 卷号 | 109期号:16页码:2573-+ |
| 摘要 | Early-life inflammation increases the risk for depression in later life. Here, we demonstrate how early-life inflammation causes adolescent depressive-like symptoms: by altering the long-term neuronal spine engulfment capacity of microglia. For mice exposed to lipopolysaccharide (LPS)-induced inflammation via the Toll-like receptor 4/NF-kappa B signaling pathway at postnatal day (P) 14, ongoing longitudinal imaging of the living brain revealed that later stress (delivered during adolescence on P45) increases the extent of microglial engulfment around anterior cingulate cortex (ACC) glutamatergic neuronal (ACC(Glu)) spines. When the ACC microglia of LPS-treated mice were deleted or chemically inhibited, the mice did not exhibit depressive-like behaviors during adolescence. Moreover, we show that the fractalkine receptor CX3CR1 mediates stress-induced engulfment of ACC(Glu) neuronal spines. Together, our findings establish that early-life inflammation causes dysregulation of microglial engulfment capacity, which encodes long-lasting maladaptation of ACC(Glu) neurons to stress, thus promoting development of depression-like symptoms during adolescence. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13521
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| 专题 | 科研部门_学习记忆的分子神经机制（徐林）
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推荐引用方式
GB/T 7714 |
Cao, P,Chen, CM,Liu, A,et al. Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines[J]. NEURON,2021,109(16):2573-+.
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| APA |
Cao, P.,Chen, CM.,Liu, A.,Shan, QH.,Zhu, X.,...&Zhang, Z.(2021).Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines.NEURON,109(16),2573-+.
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| MLA |
Cao, P,et al."Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines".NEURON 109.16(2021):2573-+.
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