| Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice | |
Chen, L ; Gong, WK; Yang, CP; Shao, CC; Song, NN; Chen, JY; Zhou, LQ; Zhang, KS; Li, SG; Huang, ZL; Richter-Levin, G; Xu, L; Ding, YQ
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| 2021 | |
| 发表期刊 | TRANSLATIONAL PSYCHIATRY
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| ISSN | 2158-3188 |
| 卷号 | 11期号:1 |
| 摘要 | Serotonin (5-HT)-based antidepressants, selective serotonin reuptake inhibitors (SSRIs) aim to enhance serotonergic activity by blocking its reuptake. We propose PTEN as a target for an alternative approach for regulating 5-HT neuron activity in the brain and depressive behaviors. We show that PTEN is elevated in central 5-HT neurons in the raphe nucleus by chronic stress in mice, and selective deletion of Pten in the 5-HT neurons induces its structural plasticity shown by increases of dendritic branching and density of PSD95-positive puncta in the dendrites. 5-HT levels are elevated and electrical stimulation of raphe neurons evokes more 5-HT release in the brain of condition knockout (cKO) mice with Pten-deficient 5-HT neurons. In addition, the 5-HT neurons remain normal electrophysiological properties but have increased excitatory synaptic inputs. Single-cell RNA sequencing revealed gene transcript alterations that may underlay morphological and functional changes in Pten-deficient 5-HT neurons. Finally, Pten cKO mice and wild-type mice treated with systemic application of PTEN inhibitor display reduced depression-like behaviors. Thus, PTEN is an intrinsic regulator of 5-HT neuron activity, representing a novel therapeutic strategy for producing antidepressant action. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13524 |
| 专题 | 科研部门_学习记忆的分子神经机制（徐林） |
| 推荐引用方式 GB/T 7714 | Chen, L,Gong, WK,Yang, CP,et al. Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice[J]. TRANSLATIONAL PSYCHIATRY,2021,11(1). |
| APA | Chen, L.,Gong, WK.,Yang, CP.,Shao, CC.,Song, NN.,...&Ding, YQ.(2021).Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice.TRANSLATIONAL PSYCHIATRY,11(1). |
| MLA | Chen, L,et al."Pten is a key intrinsic factor regulating raphe 5-HT neuronal plasticity and depressive behaviors in mice".TRANSLATIONAL PSYCHIATRY 11.1(2021). |
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| 2023031413.pdf（3824KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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