Melanopsin retinal ganglion cells mediate light-promoted brain development

	Melanopsin retinal ganglion cells mediate light-promoted brain development
	Hu, JX; Shi, YM; Zhang, JM; Huang, XF; Wang, Q; Zhao, H; Shen, JW; Chen, ZP; Song, W; Zheng, P; Zhan, SL; Sun, YP; Cai, PF; An, K; Ouyang, CJ; Zhao, BZ; Zhou, QX; Xu, L; Xiong, W; Zhang, Z; Meng, JJ; Chen, JT; Ma, YQ; Zhao, H; Zhang, M; Qu, K; Hu, J; Luo, MH; Xu, FQ; Chen, XW; Xiong, Y; Bao, J; Xue, T
	2022
发表期刊	CELL
ISSN	0092-8674
卷号	185 期号:17 页码:3124-+
摘要	During development, melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs) become light sensitive much earlier than rods and cones. IpRGCs project to many subcortical areas, whereas physiological functions of these projections are yet to be fully elucidated. Here, we found that ipRGC-medi-ated light sensation promotes synaptogenesis of pyramidal neurons in various cortices and the hippocam-pus. This phenomenon depends on activation of ipRGCs and is mediated by the release of oxytocin from the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) into cerebral-spinal fluid. We further characterized a direct connection between ipRGCs and oxytocin neurons in the SON and mutual projections between oxytocin neurons in the SON and PVN. Moreover, we showed that the lack of ipRGC-mediated, light -promoted early cortical synaptogenesis compromised learning ability in adult mice. Our results highlight the importance of light sensation early in life on the development of learning ability and therefore call attention to suitable light environment for infant care.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13526
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Hu, JX,Shi, YM,Zhang, JM,et al. Melanopsin retinal ganglion cells mediate light-promoted brain development[J]. CELL,2022,185(17):3124-+.
APA	Hu, JX.,Shi, YM.,Zhang, JM.,Huang, XF.,Wang, Q.,...&Xue, T.(2022).Melanopsin retinal ganglion cells mediate light-promoted brain development.CELL,185(17),3124-+.
MLA	Hu, JX,et al."Melanopsin retinal ganglion cells mediate light-promoted brain development".CELL 185.17(2022):3124-+.

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