The role of PTEN in primary sensory neurons in processing itch and thermal information in mice

	The role of PTEN in primary sensory neurons in processing itch and thermal information in mice
	Hu, L; Jiang, GY; Wang, YP; Hu, ZB; Zhou, BY; Zhang, L; Song, NN; Huang, Y; Chai, GD; Chen, JY; Lang, B; Xu, L; Liu, JL; Li, Y; Wang, QX; Ding, YQ
	2022
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	39 期号:3
摘要	PTEN is known as a tumor suppressor and plays essential roles in brain development. Here, we report that PTEN in primary sensory neurons is involved in processing itch and thermal information in adult mice. Deletion of PTEN in the dorsal root ganglia (DRG) is achieved in adult Drg11-Cre(ER): PTENflox/flox (PTEN CKO) mice with oral administration of tamoxifen, and CKO mice develop pathological itch and elevated itch responses on exposure to various pruritogens. PTEN deletion leads to ectopic expression of TRPV1 and MrgprA3 in IB4(+) non-peptidergic DRG neurons, and the TRPV1 is responsive to capsaicin. Importantly, the elevated itch responses are no longer present in Drg11-Cre(ER): PTENflox/flox: TRPV1(flox/flox)(PTEN: TRPV1 dCKO) mice. In addition, thermal stimulation is enhanced in PTEN CKO mice but blunted in dCKO mice. PTEN-involved regulation of itch-related gene expression in DRG neurons provides insights for understanding molecular mechanism of itch and thermal sensation at the spinal level.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13530
专题	科研部门_学习记忆的分子神经机制（徐林）
推荐引用方式 GB/T 7714	Hu, L,Jiang, GY,Wang, YP,et al. The role of PTEN in primary sensory neurons in processing itch and thermal information in mice[J]. CELL REPORTS,2022,39(3).
APA	Hu, L.,Jiang, GY.,Wang, YP.,Hu, ZB.,Zhou, BY.,...&Ding, YQ.(2022).The role of PTEN in primary sensory neurons in processing itch and thermal information in mice.CELL REPORTS,39(3).
MLA	Hu, L,et al."The role of PTEN in primary sensory neurons in processing itch and thermal information in mice".CELL REPORTS 39.3(2022).

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