| Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development |
| Shi, L; Luo, X; Jiang, J; Chen, YC; Liu, CR; Hu, T; Li, M; Lin, Q; Li, YJ ; Huang, J; Wang, H; Niu, YY; Shi, YD; Styner, M; Wang, JH; Lu, Y; Sun, XJ; Yu, HL; Ji, WZ; Su, B
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| 2019
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| 发表期刊 | NATIONAL SCIENCE REVIEW
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| ISSN | 2095-5138
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| 卷号 | 6期号:3页码:480-493 |
| 摘要 | Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys (8 first-generation and 3 second-generation) carrying human copies of MCPH1, an important gene for brain development and brain evolution. Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation, resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys, similar to the known evolutionary change of developmental delay (neoteny) in humans. Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes, providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys. More importantly, the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task. The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13536
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| 专题 | 科研部门_比较基因组学（宿兵）
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推荐引用方式
GB/T 7714 |
Shi, L,Luo, X,Jiang, J,et al. Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development[J]. NATIONAL SCIENCE REVIEW,2019,6(3):480-493.
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| APA |
Shi, L.,Luo, X.,Jiang, J.,Chen, YC.,Liu, CR.,...&Su, B.(2019).Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development.NATIONAL SCIENCE REVIEW,6(3),480-493.
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| MLA |
Shi, L,et al."Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development".NATIONAL SCIENCE REVIEW 6.3(2019):480-493.
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