The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests
	Zhang, XM; Liu, Q; Zhang, H; Zhao, SL; Huang, JH; Sovannary, T; Bunnath, L; Aun, HS; Samnom, H; Su, B; Chen, H
	2022
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	9 期号:3
摘要	Southeast Asian aborigines, the hunter-gatherer populations living in tropical rainforests, exhibit distinct morphological phenotypes, including short stature, dark skin, curly hair and a wide and snub nose. The underlying genetic architecture and evolutionary mechanism of these phenotypes remain a long-term mystery. We conducted whole genome deep sequencing of 81 Cambodian aborigines from eight ethnic groups. Through a genome-wide scan of selective sweeps, we discovered key genes harboring Cambodian-enriched mutations that may contribute to their phenotypes, including two hair morphogenesis genes (TCHH and TCHHL1), one nasal morphology gene (PAX3) and a set of genes (such as ENTPD1-AS1) associated with short stature. The identified new genes and novel mutations suggest an independent origin of the distinct phenotypes in Cambodian aborigines through parallel evolution, refuting the long-standing argument on the common ancestry of these phenotypes among the worldwide rainforest hunter-gatherers. Notably, our discovery reveals that various types of molecular mechanisms, including antisense transcription and epigenetic regulation, contribute to human morphogenesis, providing novel insights into the genetics of human environmental adaptation.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13539
专题	科研部门_比较基因组学（宿兵）
推荐引用方式 GB/T 7714	Zhang, XM,Liu, Q,Zhang, H,et al. The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests[J]. NATIONAL SCIENCE REVIEW,2022,9(3).
APA	Zhang, XM.,Liu, Q.,Zhang, H.,Zhao, SL.,Huang, JH.,...&Chen, H.(2022).The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests.NATIONAL SCIENCE REVIEW,9(3).
MLA	Zhang, XM,et al."The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests".NATIONAL SCIENCE REVIEW 9.3(2022).

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