A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication

	A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication
	Zhou, QJ; Liu, XY; Zhang, LL; Wang, R; Yin, TT; Li, XL; Li, GM; He, YQ; Ding, ZL; Ma, PC; Wang, SZ; Mao, BY; Zhang, SH; Wang, GD
	2022
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	9 期号:11
摘要	The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves. Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory, such as long-term potentiation and long-term depression. In this study, we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types, cell lineage and molecular features. Using the transcriptomes of 105 057 nuclei from the hippocampus of a Beagle dog, we identified 26 cell clusters and a putative trajectory of oligodendrocyte development. Comparative analysis revealed a significant convergence between dog differentially expressed genes (DEGs) and putative positively selected genes (PSGs). Forty putative PSGs were DEGs in glutamatergic neurons, especially in Cluster 14, which is related to the regulation of nervous system development. In summary, this study provides a blueprint to understand the cellular mechanism of dog domestication.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13551
专题	科研部门_行为遗传与进化（王国栋）
推荐引用方式 GB/T 7714	Zhou, QJ,Liu, XY,Zhang, LL,et al. A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication[J]. NATIONAL SCIENCE REVIEW,2022,9(11).
APA	Zhou, QJ.,Liu, XY.,Zhang, LL.,Wang, R.,Yin, TT.,...&Wang, GD.(2022).A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication.NATIONAL SCIENCE REVIEW,9(11).
MLA	Zhou, QJ,et al."A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication".NATIONAL SCIENCE REVIEW 9.11(2022).

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