Long-Read Genome Sequencing Provides Molecular Insights into Scavenging and Societal Complexity in Spotted Hyena Crocuta crocuta

	Long-Read Genome Sequencing Provides Molecular Insights into Scavenging and Societal Complexity in Spotted Hyena Crocuta crocuta
	Shao, Y; Wang, XB; Zhang, ML; Liu, Y; Wang, S; Zhang, BL; Yang, MM; Yang, MH; Jia, T; Pu, TC; Lu, Y; Liu, H; Xu, Z; Li, B; Liu, N; Onsongo, VM; Wu, DD; Zhang, CL; Ruan, J; Li, Y
	2022
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	39 期号:3
摘要	The spotted hyena (Crocuta crocuta) is a large and unique terrestrial carnivore. It is a particularly fascinating species due to its distinct phenotypic traits, especially its complex social structure and scavenging lifestyle, with associated high dietary exposure to microbial pathogens. However, the underlying molecular mechanisms related to these phenotypes remain elusive. Here, we sequenced and assembled a high-quality long-read genome of the spotted hyena, with a contig N50 length of similar to 13.75 Mb. Based on comparative genomics, immunoglobulin family members (e.g., IGKV4-1) showed significant adaptive duplications in the spotted hyena and striped hyena. Furthermore, immune-related genes (e.g., CD8A, LAG3, and TLR3) experienced species-specific positive selection in the spotted hyena lineage. These results suggest that immune tolerance between the spotted hyena and closely related striped hyena has undergone adaptive divergence to cope with prolonged dietary exposure to microbial pathogens from scavenging. Furthermore, we provided the potential genetic insights underlying social complexity, hinting at social behavior and cognition. Specifically, the RECNE-associated genes (e.g., UGP2 and ACTR2) in the spotted hyena genome are involved in regulation of social communication. Taken together, our genomic analyses provide molecular insights into the scavenging lifestyle and societal complexity of spotted hyenas.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13554
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Shao, Y,Wang, XB,Zhang, ML,et al. Long-Read Genome Sequencing Provides Molecular Insights into Scavenging and Societal Complexity in Spotted Hyena Crocuta crocuta[J]. MOLECULAR BIOLOGY AND EVOLUTION,2022,39(3).
APA	Shao, Y.,Wang, XB.,Zhang, ML.,Liu, Y.,Wang, S.,...&Li, Y.(2022).Long-Read Genome Sequencing Provides Molecular Insights into Scavenging and Societal Complexity in Spotted Hyena Crocuta crocuta.MOLECULAR BIOLOGY AND EVOLUTION,39(3).
MLA	Shao, Y,et al."Long-Read Genome Sequencing Provides Molecular Insights into Scavenging and Societal Complexity in Spotted Hyena Crocuta crocuta".MOLECULAR BIOLOGY AND EVOLUTION 39.3(2022).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023041106.pdf（900KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文