| Ruminant-specific genes identified using high-quality genome data and their roles in rumen evolution |
| Chen, CY; Yin, Y; Li, HR; Zhou, BT; Zhou, J; Zhou, XF; Li, ZP; Liu, GC; Pan, XY; Zhang, R; Lin, ZS; Chen, L ; Qiu, Q; Zhang, YE; Wang, W
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| 2022
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| 发表期刊 | SCIENCE BULLETIN
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| ISSN | 2095-9273
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| 卷号 | 67期号:8页码:825-835 |
| 摘要 | Ruminants comprise a highly successful group of mammals with striking morphological innovations, including the presence of a rumen. Many studies have shown that species-specific or lineage-specific genes (referred to as new genes) play important roles in phenotypic evolution. In this study, we identified 1064 ruminant-specific genes based on the newly assembled high-quality genomes of representative members of two ruminant families and other publically available high-quality genomes. Ruminant-specific genes shared similar evolutionary and expression patterns with new genes found in other mam-mals, such as primates and rodents. Most new genes were derived from gene duplication and tended to be expressed in the testes or immune-related tissues, but were depleted in the adult brain. We also found that most genes expressed in the rumen were genes predating sheep-sperm whale split (referred to as old genes), but some new genes were also involved in the evolution of the rumen, and contributed more during rumen development than in the adult rumen. Notably, expression levels of members of the ruminant-specific PRD-SPRRII gene family, which are subject to positive selection, varied throughout rumen development and may thus play important roles in the development of the keratin-rich surface of the rumen. Overall, this study generated two novel ruminant genomes and also provided novel insights into the evolution of new mammalian organs.(c) 2022 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13574
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| 专题 | 基因起源组
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推荐引用方式
GB/T 7714 |
Chen, CY,Yin, Y,Li, HR,et al. Ruminant-specific genes identified using high-quality genome data and their roles in rumen evolution[J]. SCIENCE BULLETIN,2022,67(8):825-835.
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| APA |
Chen, CY.,Yin, Y.,Li, HR.,Zhou, BT.,Zhou, J.,...&Wang, W.(2022).Ruminant-specific genes identified using high-quality genome data and their roles in rumen evolution.SCIENCE BULLETIN,67(8),825-835.
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| MLA |
Chen, CY,et al."Ruminant-specific genes identified using high-quality genome data and their roles in rumen evolution".SCIENCE BULLETIN 67.8(2022):825-835.
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