Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus)

KIZ OpenIR > 基因起源组（王文）

	Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus)
	Lin, ZS; Chen, L; Chen, XQ; Zhong, YB; Yang, Y; Xia, WH; Liu, C; Zhu, WB; Wang, H; Yan, BY; Yang, YF; Liu, X; Kvie, KS; Roed, KH; Wang, K; Xiao, WH; Wei, HJ; Li, GY; Heller, R; Gilbert, MTP; Qiu, Q; Wang, W; Li, ZP
	2019
发表期刊	SCIENCE
ISSN	0036-8075
卷号	364 期号:6446 页码:1154-+
摘要	The reindeer is an Arctic species that exhibits distinctive biological characteristics, for which the underlying genetic basis remains largely unknown. We compared the genomes of reindeer against those of other ruminants and nonruminant mammals to reveal the genetic basis of light arrhythmicity, high vitamin D metabolic efficiency, the antler growth trait of females, and docility. We validate that two reindeer vitamin D metabolic genes (CYP27B1 and POR) show signs of positive selection and exhibit higher catalytic activity than those of other ruminants. A mutation upstream of the reindeer CCND1 gene endows an extra functional binding motif of the androgen receptor and thereby may result in female antlers. Furthermore, a mutation (proline-1172 -> threonine) in reindeer PER2 results in loss of binding ability with CRY1, which may explain circadian arrhythmicity in reindeer.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13575
专题	基因起源组（王文）
推荐引用方式 GB/T 7714	Lin, ZS,Chen, L,Chen, XQ,et al. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus)[J]. SCIENCE,2019,364(6446):1154-+.
APA	Lin, ZS.,Chen, L.,Chen, XQ.,Zhong, YB.,Yang, Y.,...&Li, ZP.(2019).Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus).SCIENCE,364(6446),1154-+.
MLA	Lin, ZS,et al."Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus)".SCIENCE 364.6446(2019):1154-+.

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2023031511.pdf（1643KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文