| Allele-specific expression and alternative splicing in horsexdonkey and cattlexyak hybrids |
| Wang, Y; Gao, S; Zhao, Y; Chen, WH; Shao, JJ; Wang, NN; Li, M; Zhou, GX; Wang, L; Shen, WJ; Xu, JT; Deng, WD; Wang, W; Chen, YL; Jiang, Y
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| 2019
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| 发表期刊 | ZOOLOGICAL RESEARCH
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| ISSN | 2095-8137
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| 卷号 | 40期号:4页码:293-304 |
| 摘要 | Divergence of gene expression and alternative splicing is a crucial driving force in the evolution of species; to date, however the molecular mechanism remains unclear. Hybrids of closely related species provide a suitable model to analyze allele-specific expression (ASE) and allele-specific alternative splicing (ASS). Analysis of ASE and ASS can uncover the differences in cis-regulatory elements between closely related species, while eliminating interference of trans-regulatory elements. Here, we provide a detailed characterization of ASE and ASS from 19 and 10 transcriptome datasets across five tissues from reciprocal-cross hybrids of horsex donkey (mule/hinny) and cattlexyak (dzo), respectively. Results showed that 4.8% - 8.7% and 10.8%-16.7% of genes exhibited ASE and ASS, respectively. Notably, lncRNAs and pseudogenes were more likely to show ASE than protein-coding genes. In addition, genes showing ASE and ASS in mule/hinny were found to be involved in the regulation of muscle strength, whereas those of dzo were involved in high-altitude adaptation. In conclusion, our study demonstrated that exploration of genes showing ASE and ASS in hybrids of closely related species is feasible for species evolution research. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13578
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| 专题 | 基因起源组
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推荐引用方式
GB/T 7714 |
Wang, Y,Gao, S,Zhao, Y,et al. Allele-specific expression and alternative splicing in horsexdonkey and cattlexyak hybrids[J]. ZOOLOGICAL RESEARCH,2019,40(4):293-304.
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| APA |
Wang, Y.,Gao, S.,Zhao, Y.,Chen, WH.,Shao, JJ.,...&Jiang, Y.(2019).Allele-specific expression and alternative splicing in horsexdonkey and cattlexyak hybrids.ZOOLOGICAL RESEARCH,40(4),293-304.
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| MLA |
Wang, Y,et al."Allele-specific expression and alternative splicing in horsexdonkey and cattlexyak hybrids".ZOOLOGICAL RESEARCH 40.4(2019):293-304.
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