Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice

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	Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice
	Peng, Y; Zhang, YY; Gui, YJ; An, D; Liu, JZ; Xu, X; Li, Q; Wang, JM; Wang, W; Shi, CH; Fan, LJ; Lu, BR; Deng, YW; Teng, S; He, ZH
	2019
发表期刊	MOLECULAR PLANT
ISSN	1674-2052
卷号	12 期号:10 页码:1395-1407
摘要	Transposable elements (TEs) constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution. They also play important roles in crop domestication. However, whether TEs themselves are also selected during crop domestication has remained unknown. Here, we identify an active long terminal repeat (LTR) retrotransposon, HUO, as a potential target of selection during rice domestication and breeding. HUO is a low-copy-number LTR retrotransposon, and is active under natural growth conditions and transmitted through male gametogenesis, preferentially inserting into genomic regions capable of transcription. HUO exists in all wild rice accessions and about half of the archaeological rice grains (1200-7000 years ago) and landraces surveyed, but is absent in almost all modern varieties, indicating its gradual elimination during rice domestication and breeding. Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway. Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression, resulting in decreased disease resistance and yield, coinciding with its elimination during rice breeding. Together, our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13579
专题	基因起源组
推荐引用方式 GB/T 7714	Peng, Y,Zhang, YY,Gui, YJ,et al. Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice[J]. MOLECULAR PLANT,2019,12(10):1395-1407.
APA	Peng, Y.,Zhang, YY.,Gui, YJ.,An, D.,Liu, JZ.,...&He, ZH.(2019).Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice.MOLECULAR PLANT,12(10),1395-1407.
MLA	Peng, Y,et al."Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice".MOLECULAR PLANT 12.10(2019):1395-1407.

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