The origin of domestication genes in goats

KIZ OpenIR > 基因起源组

	The origin of domestication genes in goats
	Zheng, ZQ; Wang, XH; Li, M; Li, YJ; Yang, ZR; Wang, XL; Pan, XY; Gong, MA; Zhang, Y; Guo, YW; Wang, Y; Liu, J; Cai, YD; Chen, QM; Okpeku, M; Colli, L; Cai, DW; Kun, W; Huang, SS; Sonstegard, TS; Esmailizadeh, A; Zhang, WG; Zhang, TT; Xu, YB; Xu, NY; Yang, Y; Han, JL; Chen, L; Lesur, J; Daly, K; Bradley, DG; Heller, R; Zhang, GJ; Wang, W; Chen, YL; Jiang, Y
	2020
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	6 期号:21
摘要	Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically cryptic evolutionary transformations provides new insights into the mechanisms of animal domestication.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13587
专题	基因起源组
推荐引用方式 GB/T 7714	Zheng, ZQ,Wang, XH,Li, M,et al. The origin of domestication genes in goats[J]. SCIENCE ADVANCES,2020,6(21).
APA	Zheng, ZQ.,Wang, XH.,Li, M.,Li, YJ.,Yang, ZR.,...&Jiang, Y.(2020).The origin of domestication genes in goats.SCIENCE ADVANCES,6(21).
MLA	Zheng, ZQ,et al."The origin of domestication genes in goats".SCIENCE ADVANCES 6.21(2020).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023031531.pdf（2314KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文