SiO(2)prompts host defense againstAcinetobacter baumanniiinfection by mTORC1 activation

	SiO(2)prompts host defense againstAcinetobacter baumanniiinfection by mTORC1 activation
	Guo, XM; Wang, CM; Xu, T; Yang, L; Liu, CH; Qi, XP
	2021
发表期刊	SCIENCE CHINA-LIFE SCIENCES
ISSN	1674-7305
卷号	64 期号:6 页码:982-990
摘要	Host-pathogen interactions in the setting of chronic pulmonary inflammation remain unclear, and the occurrence of pneumonia is increased in patients with chronic obstructive pulmonary disease who use immunosuppressive drugs. We performedAcinetobacter baumanniiinfection in mice with chronic pulmonary inflammation after intranasal administration of SiO(2)and found SiO(2)treatment increased host defense againstA. baumanniiinfection. Innate immune responses initiated by NF-kappa B, type 1 interferon, NLRP3 and AIM2 inflammasomes were dispensable for SiO2-mediated host defense. SiO(2)treatment activated the mTORC1 signaling, and mTORC1 was crucial for host defense againstA. baumanniiinfection. Our study highlights the protective role of mTORC1 signaling in host defense against bacterial infection, offers novel insights into understanding the mechanisms of immunosuppressive drug-related pneumonia, and provides potential host-directed therapeutics to treat bacterial infections.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13595
专题	科研部门_病原菌感染与宿主免疫机制（齐晓朋）
推荐引用方式 GB/T 7714	Guo, XM,Wang, CM,Xu, T,et al. SiO(2)prompts host defense againstAcinetobacter baumanniiinfection by mTORC1 activation[J]. SCIENCE CHINA-LIFE SCIENCES,2021,64(6):982-990.
APA	Guo, XM,Wang, CM,Xu, T,Yang, L,Liu, CH,&Qi, XP.(2021).SiO(2)prompts host defense againstAcinetobacter baumanniiinfection by mTORC1 activation.SCIENCE CHINA-LIFE SCIENCES,64(6),982-990.
MLA	Guo, XM,et al."SiO(2)prompts host defense againstAcinetobacter baumanniiinfection by mTORC1 activation".SCIENCE CHINA-LIFE SCIENCES 64.6(2021):982-990.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023041105.pdf（4597KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文