RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense

	RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense
	Guo, XM; Ma, PC; Li, YW; Yang, YN; Wang, CM; Xu, T; Wang, HS; Li, CC; Mao, BY; Qi, XP
	2021
发表期刊	CELL DEATH AND DIFFERENTIATION
ISSN	1350-9047
卷号	28 期号:2 页码:640-656
摘要	STAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated and activated upon IFN signaling remain elusive. Our work demonstrated that ubiquitination of STAT1 mediated by the E3 ligase RNF220 contributed significantly to STAT1 activation and innate immune responses.Rnf220gene deficiency resulted in the downregulation of IFN signaling and decreased expression of ISGs in response to type 1 and 2 IFNs stimulation andAcinetobacter baumanniiand HSV-1 infection. Mechanistically, RNF220 interacted with STAT1 and mediated the K63-linked polyubiquitination of STAT1 at residue K110, which promoted the interaction between STAT1 and the kinase JAK1. The expression of RNF220 was induced by pathogenic infection and IFN signaling. RNF220 promoted STAT1 ubiquitination and phosphorylation through a positive feedback loop. RNF220 haploinsufficiency impaired IFN signaling, and RNF220-defective mice were more susceptible toA. baumanniiand HSV-1 infection than WT mice. Our work offers novel insights into the mechanisms of STAT1 modulation and provides potential therapeutic targets against bacterial and viral infection and inflammatory diseases.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13597
专题	科研部门_病原菌感染与宿主免疫机制（齐晓朋）
推荐引用方式 GB/T 7714	Guo, XM,Ma, PC,Li, YW,et al. RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense[J]. CELL DEATH AND DIFFERENTIATION,2021,28(2):640-656.
APA	Guo, XM.,Ma, PC.,Li, YW.,Yang, YN.,Wang, CM.,...&Qi, XP.(2021).RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense.CELL DEATH AND DIFFERENTIATION,28(2),640-656.
MLA	Guo, XM,et al."RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense".CELL DEATH AND DIFFERENTIATION 28.2(2021):640-656.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023041107.pdf（6367KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文