Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection

	Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection
	Guo, Y; Mao, RD; Xie, QQ; Cheng, XJ; Xu, T; Wang, XY; Du, Y; Qi, XP
	2021
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
卷号	9
摘要	Bacterial infection tendentiously triggers inflammasome activation, whereas the roles of inflammasome activation in host defense against diverse infections remain unclear. Here, we identified that an ASC-dependent inflammasome activation played opposite roles in host defense against Francisella novicida wild-type (WT) U112 and mutant strain XWK4. Comparing with U112, XWK4 infection induced robust cytokine production, ASC-dependent inflammasome activation, and pyroptosis. Both AIM2 and NLRP3 were involved and played independent roles in XWK4-induced inflammasome activation. Type II interferon was partially required for XWK4-triggered inflammasome activation, which was different from type I interferon dependency in U112-induced inflammasome activation. Distinct from F. novicida U112 and Acinetobacter baumannii infection, Asc(-/-) mice were more resistant than WT mice response to XWK4 infection by limiting bacterial burden in vivo. The excessive inflammasome activation triggered by XWK4 infection caused dramatical cell death and pathological damage. Our study offers novel insights into mechanisms of inflammasome activation in host defense and provides potential therapeutic approach against bacterial infections and inflammatory diseases.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13598
专题	科研部门_病原菌感染与宿主免疫机制（齐晓朋）
推荐引用方式 GB/T 7714	Guo, Y,Mao, RD,Xie, QQ,et al. Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2021,9.
APA	Guo, Y.,Mao, RD.,Xie, QQ.,Cheng, XJ.,Xu, T.,...&Qi, XP.(2021).Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9.
MLA	Guo, Y,et al."Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021).

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