Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys

	Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys
	Zhang, B; Xiong, F; Ma, YY; Li, B; Mao, Y; Zhou, Z; Yu, HL; Li, JH; Li, CY; Fu, J; Wang, JH; Zhao, XD
	2019
发表期刊	PSYCHOPHARMACOLOGY
ISSN	0033-3158
卷号	236 期号:7 页码:2223-2232
摘要	RationalePhencyclidine (PCP) could induce schizophrenia (Sz) like behavior in both humans and animals, therefore, has been widely utilized to establish Sz animal models. It induced cognitive deficits, the core symptom of Sz, mainly through influencing frontal dopaminergic function. Nonhuman primate (NHP) studies demonstrated impaired object retrieval detour (ORD) and spatial delayed response (SDR) task performance by acute or chronic PCP treatment. However, NHP investigations, continually monitoring SDR performance before, during and after PCP treatment, are lacking.ObjectivesPresent study investigated the long-term influence of chronic PCP treatment on SDR performance and the possible increase of SDR deficit severity and duration by the incremental dosing procedure in rhesus monkeys.MethodsSDR task was performed repeatedly up to eight weeks after constant dosing procedure (i.m., 0.3 mg/kg, day 12-25), during which drug effects on locomotor activity and blood cortisol concentration were assessed. Incremental dosing procedure (starting dose 0.3 mg/kg, day 6-19) began five months later.ResultsConstant dosing procedure induced differential level of hyperactivity across testing days, without significant influence on blood cortisol concentration. It reduced SDR performance, until occurrence of the first and worst impairment on day 15 and 23 respectively. The impaired performance recovered to pretreatment level over one week after drug cessation. In contrast, incremental dosing procedure impaired SDR performance on the first treatment day, which recovered within treatment period.ConclusionResults suggested increase of SDR deficit severity by repeated PCP administrations, whereas the incremental dosing procedure did not increase SDR deficit severity and duration.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13605
专题	科研部门_肿瘤干细胞生物学（赵旭东）
推荐引用方式 GB/T 7714	Zhang, B,Xiong, F,Ma, YY,et al. Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys[J]. PSYCHOPHARMACOLOGY,2019,236(7):2223-2232.
APA	Zhang, B.,Xiong, F.,Ma, YY.,Li, B.,Mao, Y.,...&Zhao, XD.(2019).Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys.PSYCHOPHARMACOLOGY,236(7),2223-2232.
MLA	Zhang, B,et al."Chronic phencyclidine treatment impairs spatial working memory in rhesus monkeys".PSYCHOPHARMACOLOGY 236.7(2019):2223-2232.

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