Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents

	Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents
	Peng, W; Hegazy, AM; Jiang, N; Chen, X; Qi, HX; Zhao, XB; Pu, J; Ye, RR; Li, RT
	2020
发表期刊	JOURNAL OF INORGANIC BIOCHEMISTRY
ISSN	0162-0134
卷号	203
摘要	Glioma stem cells (GSCs) are thought to be responsible for the recurrence and invasion of glioblastoma multiform (GBM), which have been evaluated and exploited as the therapeutic target for GBM. Cyclometalated iridium(III) complexes have been demonstrated as the potential anticancer agents, however, their antitumor efficacies against GSCs are still unknown. Herein, we investigated the antitumor activity of two cyclometalated iridium(III) complexes [Ir(ppy)(2)L](PF6) (Ir1) and [Ir(thpy)(2)L](PF6) (Ir2) (ppy = 2-phenylpyridine, thpy = 2-(2-thienyl)pyridine and L = 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine) against GSCs. The results clearly indicate that Ir1 and Ir2 kill GSCs selectively with IC50 values ranging from 5.26-9.05 mu M. Further mechanism research display that Ir1 and Ir2 can suppress the proliferation of GSCs, penetrate into GSCs efficiently, localize to mitochondria, and induce mitochondria-mediated apoptosis, including the loss of mitochondrial membrane (MMP), elevation of intracellular reactive oxygen species (ROS) and caspases activation. Moreover, Ir1 and Ir2 can destroy the GSCs self-renewal and unlimited proliferation capacity by affecting the GSCs colony formation. According our knowledge, this is the first study to investigate the anti-GSCs properties of cyclometalated iridium (III) complexes.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13607
专题	科研部门_肿瘤干细胞生物学（赵旭东）
推荐引用方式 GB/T 7714	Peng, W,Hegazy, AM,Jiang, N,et al. Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2020,203.
APA	Peng, W.,Hegazy, AM.,Jiang, N.,Chen, X.,Qi, HX.,...&Li, RT.(2020).Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents.JOURNAL OF INORGANIC BIOCHEMISTRY,203.
MLA	Peng, W,et al."Identification of two mitochondrial-targeting cyclometalated iridium(III) complexes as potent anti-glioma stem cells agents".JOURNAL OF INORGANIC BIOCHEMISTRY 203(2020).

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