| Pore-forming protein beta gamma-CAT promptly responses to fasting with capacity to deliver macromolecular nutrients |
| Shi, ZH; Zhao, Z; Liu, LZ; Bian, XL; Zhang, Y
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| 2022
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| 发表期刊 | FASEB JOURNAL
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| ISSN | 0892-6638
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| 卷号 | 36期号:10 |
| 摘要 | During animal fasting, the nutrient supply and metabolism switch from carbohydrates to a new reliance on the catabolism of energy-dense lipid stores. Assembled under tight regulation, beta gamma-CAT (a complex of non-lens beta gamma-crystallin and trefoil factor) is a pore-forming protein and trefoil factor complex identified in toad Bombina maxima. Here, we determined that this protein complex is a constitutive component in toad blood, that actively responds to the animal fasting. The protein complex was able to promote cellular albumin and albumin-bound fatty acid (FA) uptake in a variety of epithelial and endothelial cells, and the effects were attenuated by a macropinocytosis inhibitor. Endothelial cell-derived exosomes containing largely enriched albumin and FAs, called nutrisomes, were released in the presence of beta gamma-CAT. These specific nutrient vesicles were readily taken up by starved myoblast cells to support their survival. The results uncovered that pore-forming protein beta gamma-CAT is a fasting responsive element able to drive cell vesicular import and export of macromolecular nutrients. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13615
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| 专题 | 科研部门_生物毒素与人类疾病（张云）
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推荐引用方式
GB/T 7714 |
Shi, ZH,Zhao, Z,Liu, LZ,et al. Pore-forming protein beta gamma-CAT promptly responses to fasting with capacity to deliver macromolecular nutrients[J]. FASEB JOURNAL,2022,36(10).
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| APA |
Shi, ZH,Zhao, Z,Liu, LZ,Bian, XL,&Zhang, Y.(2022).Pore-forming protein beta gamma-CAT promptly responses to fasting with capacity to deliver macromolecular nutrients.FASEB JOURNAL,36(10).
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| MLA |
Shi, ZH,et al."Pore-forming protein beta gamma-CAT promptly responses to fasting with capacity to deliver macromolecular nutrients".FASEB JOURNAL 36.10(2022).
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