Animal secretory endolysosome channel discovery

	Animal secretory endolysosome channel discovery
	Zhang, Y; Wang, QQ; Zhao, Z; Deng, CJ
	2021
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	42 期号:2 页码:141-152
摘要	Secretory pore-forming proteins (PFPs) have been identified in organisms from all kingdoms of life. Our studies with the toad species Bombina maxima found an interaction network among aerolysin family PFPs (af-PFPs) and trefoil factors (TFFs). As a toad af-PFP, BmALP1 can be reversibly regulated between active and inactive forms, with its paralog BmALP3 acting as a negative regulator. BmALP1 interacts with BmTFF3 to form a cellular active complex called beta gamma-CAT. This PFP complex is characterized by acting on endocytic pathways and forming pores on endolysosomes, including stimulating cell macropinocytosis. In addition, cell exocytosis can be induced and/or modulated in the presence of beta gamma-CAT. Depending on cell contexts and surroundings, these effects can facilitate the toad in material uptake and vesicular transport, while maintaining mucosal barrier function as well as immune defense. Based on experimental evidence, we hereby propose a secretory endolysosome channel (SELC) pathway conducted by a secreted PFP in cell endocytic and exocytic systems, with beta gamma-CAT being the first example of a SELC protein. With essential roles in cell interactions and environmental adaptations, the proposed SELC protein pathway should be conserved in other living organisms.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13616
专题	科研部门_生物毒素与人类疾病（张云）
推荐引用方式 GB/T 7714	Zhang, Y,Wang, QQ,Zhao, Z,et al. Animal secretory endolysosome channel discovery[J]. ZOOLOGICAL RESEARCH,2021,42(2):141-152.
APA	Zhang, Y,Wang, QQ,Zhao, Z,&Deng, CJ.(2021).Animal secretory endolysosome channel discovery.ZOOLOGICAL RESEARCH,42(2),141-152.
MLA	Zhang, Y,et al."Animal secretory endolysosome channel discovery".ZOOLOGICAL RESEARCH 42.2(2021):141-152.

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