Multiplication of defective Ebola virus in a complementary permissive cell line

	Multiplication of defective Ebola virus in a complementary permissive cell line
	Tong, XK; Li, H; Yang, L; Xie, SZ; Xie, S; Gong, Y; Peng, C; Gao, XX; Shi, ZL; Yang, XL; Zuo, JP
	2023
发表期刊	ANTIVIRAL RESEARCH
ISSN	0166-3542
卷号	209
摘要	In an effort to develop safe and innovative in vitro models for Ebola virus (EBOV) research, we generated a recombinant Ebola virus where the glycoprotein (GP) gene was substituted with the Cre recombinase (Cre) gene by reverse genetics. This defective virus could multiply itself in a complementary permissive cell line, which could express GP and reporter protein upon exogenous Cre existence. The main features of this novel model for Ebola virus are intact viral life cycle, robust virus multiplication and normal virions morphology. The design of this model ensures its safety, excellent stability and maneuverability as a tool for virology research as well as for antiviral agent screening and drug discovery, and such a design could be further adapted to other viruses.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13624
专题	科研部门_疫源动物病毒（杨兴娄）
推荐引用方式 GB/T 7714	Tong, XK,Li, H,Yang, L,et al. Multiplication of defective Ebola virus in a complementary permissive cell line[J]. ANTIVIRAL RESEARCH,2023,209.
APA	Tong, XK.,Li, H.,Yang, L.,Xie, SZ.,Xie, S.,...&Zuo, JP.(2023).Multiplication of defective Ebola virus in a complementary permissive cell line.ANTIVIRAL RESEARCH,209.
MLA	Tong, XK,et al."Multiplication of defective Ebola virus in a complementary permissive cell line".ANTIVIRAL RESEARCH 209(2023).

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