SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR

	SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR
	Zhao, LN; Qiu, T; Jiang, DW; Xu, HB; Zou, L; Yang, Q; Chen, CS; Jiao, BW
	2020
发表期刊	ADVANCED SCIENCE
卷号	7 期号:14
摘要	Breast cancer stem cells (BCSCs) are responsible for resistance to chemotherapy, high degree of metastasis, and poor prognosis, especially in triple-negative breast cancer (TNBC). The CD24(low)CD44(high) and high aldehyde dehydrogenase 1 (ALDH1) cell subpopulation (CD24(low)CD44(high) ALDH1(+)) exhibit very high tumor initiating capacity. In the current study, the upregulated genes are analyzed in both CD24(low)CD44(high) and ALDH1(+) cell populations at single-cell resolution, and a highly expressed membrane protein, SGCE, is identified in both BCSC populations. Further results show that SGCE depletion reduces BCSC self-renewal, chemoresistance, and metastasis both in vitro and in vivo, partially through affecting the accumulation of extracellular matrix (ECM). For the underlying mechanism, SGCE functions as a sponge molecule for the interaction between epidermal growth factor receptor (EGFR) and its E3 ubiquitination ligase (c-Cbl), and thus inhibits EGFR lysosomal degradation to stabilize the EGFR protein. SGCE knockdown promotes sensitivity to EGFR tyrosine kinase inhibitors (TKIs), providing new clues for deciphering the current failure of targeting EGFR in clinical trials and highlighting a novel candidate for BCSC stemness regulation.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13633
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Zhao, LN,Qiu, T,Jiang, DW,et al. SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR[J]. ADVANCED SCIENCE,2020,7(14).
APA	Zhao, LN.,Qiu, T.,Jiang, DW.,Xu, HB.,Zou, L.,...&Jiao, BW.(2020).SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR.ADVANCED SCIENCE,7(14).
MLA	Zhao, LN,et al."SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR".ADVANCED SCIENCE 7.14(2020).

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