The Roles of Alternative Splicing in Tumor-immune Cell Interactions

	The Roles of Alternative Splicing in Tumor-immune Cell Interactions
	Wang, Y; Zhang, HL; Jiao, BW; Nie, JY; Li, XY; Wang, WH; Wang, HR
	2020
发表期刊	CURRENT CANCER DRUG TARGETS
ISSN	1568-0096
卷号	20 期号:10 页码:729-740
摘要	Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and pro-tumoral roles in different types of cancer. For example, ULBP1_RI, MLL5 Delta 21spe, NKp44-1 Delta 5, MHC-I Delta 7, CD200S Delta 1, 2, PVR alpha/beta/gamma/delta and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1 Delta N100 exhibit functions in hematological cancers.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13634
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Wang, Y,Zhang, HL,Jiao, BW,et al. The Roles of Alternative Splicing in Tumor-immune Cell Interactions[J]. CURRENT CANCER DRUG TARGETS,2020,20(10):729-740.
APA	Wang, Y.,Zhang, HL.,Jiao, BW.,Nie, JY.,Li, XY.,...&Wang, HR.(2020).The Roles of Alternative Splicing in Tumor-immune Cell Interactions.CURRENT CANCER DRUG TARGETS,20(10),729-740.
MLA	Wang, Y,et al."The Roles of Alternative Splicing in Tumor-immune Cell Interactions".CURRENT CANCER DRUG TARGETS 20.10(2020):729-740.

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