Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk

	Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk
	Wang, H; Xu, HB; Chen, W; Cheng, M; Zou, L; Yang, Q; Chan, CB; Zhu, H; Chen, CS; Nie, JY; Jiao, BW
	2022
发表期刊	CANCER RESEARCH
ISSN	0008-5472
卷号	82 期号:11 页码:2124-2140
摘要	Cancer stem cells (CSC) are supported by the tumor microenvironment, and non-CSCs can regain CSC phenotypes in certain niches, leading to limited clinical benefits of CSC-targeted therapy. A better understanding of the mechanisms governing the orchestration of the CSC niche could help improve the therapeutic targeting of CSCs. Here, we report that Rab13, a small GTPase, is highly expressed in breast CSCs (BCSC). Rab13 depletion suppressed breast cancer cell stemness, tumorigenesis, and chemoresistance by reducing tumor-stroma cross-talk. Accordingly, Rab13 controlled the membrane translocation of C-X-C chemokine receptor type 1/2 (CXCR1/2), allowing tumor cells to interact with tumor-associated macrophages and cancer-associated fibroblasts to establish a supportive BCSC niche. Targeting the Rab13-mediated BCSC niche with bardoxolone-methyl (C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid; CDDO-Me) prevented BCSC stemness in vitro and in vivo. These findings highlight the novel regulatory mechanism of Rab13 in BCSC, with important implications for the development of therapeutic strategies for disrupting the BCSC niche. Significance: Targeting Rab13 perturbs formation of the breast cancer stem cell niche by inhibiting cross-talk between cancer cells and the tumor microenvironment, providing a therapeutic opportunity for niche-targeted breast cancer treatment.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13635
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Wang, H,Xu, HB,Chen, W,et al. Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk[J]. CANCER RESEARCH,2022,82(11):2124-2140.
APA	Wang, H.,Xu, HB.,Chen, W.,Cheng, M.,Zou, L.,...&Jiao, BW.(2022).Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk.CANCER RESEARCH,82(11),2124-2140.
MLA	Wang, H,et al."Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor-Stroma Cross-talk".CANCER RESEARCH 82.11(2022):2124-2140.

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