TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh

	TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh
	Zhao, LM; Ke, H; Xu, HB; Wang, GD; Zhang, HL; Zou, L; Xiang, S; Li, MY; Peng, L; Zhou, MF; Li, LL; Ao, L; Yang, Q; Shen, CKJ; Yi, P; Wang, L; Jiao, BW
	2020
发表期刊	NATURE COMMUNICATIONS
ISSN	2041-1723
卷号	11 期号:1
摘要	Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. However, the underlying molecular mechanism is less clear. Here we report that TDP-43, a RNA-binding protein, underwent positive selection in the mammalian lineage. Furthermore, TDP-43 gene (Tardbp) loss induces accumulation of large lipid droplets and severe lipid secretion deficiency in mammary epithelial cells to outside alveolar lumens, eventually resulting in lactation failure and pup starvation within three weeks postpartum. In human milk samples from lactating women, the expression levels of TDP-43 is positively correlated with higher milk output. Mechanistically, TDP-43 exerts post-transcriptional regulation of Btn1a1 and Xdh mRNA stability, which are required for the secretion of lipid droplets from epithelial cells to the lumen. Taken together, our results highlights the critical role of TDP-43 in milk lipid secretion, providing a potential strategy for the screening and intervention of clinical lactation insufficiency. Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13641
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Zhao, LM,Ke, H,Xu, HB,et al. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh[J]. NATURE COMMUNICATIONS,2020,11(1).
APA	Zhao, LM.,Ke, H.,Xu, HB.,Wang, GD.,Zhang, HL.,...&Jiao, BW.(2020).TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.NATURE COMMUNICATIONS,11(1).
MLA	Zhao, LM,et al."TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh".NATURE COMMUNICATIONS 11.1(2020).

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