Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice

	Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice
	Ahuja, P; Ng, CF; Pang, BPS; Chan, WS; Tse, MCL; Bi, XY; Kwan, HLR; Brobst, D; Herlea-Pana, O; Yang, XY; Du, GH; Saengnipanthkul, S; Noh, HL; Jiao, BW; Kim, JK; Lee, CW; Ye, KQ; Chan, CB
	2022
发表期刊	AUTOPHAGY
ISSN	1554-8627
卷号	18 期号:6 页码:1367-1384
摘要	Mitochondrial remodeling is dysregulated in metabolic diseases but the underlying mechanism is not fully understood. We report here that BDNF (brain derived neurotrophic factor) provokes mitochondrial fission and clearance in skeletal muscle via the PRKAA/AMPK-PINK1-PRKN/Parkin and PRKAA-DNM1L/DRP1-MFF pathways. Depleting Bdnf expression in myotubes reduced fatty acid-induced mitofission and mitophagy, which was associated with mitochondrial elongation and impaired lipid handling. Muscle-specific bdnf knockout (MBKO) mice displayed defective mitofission and mitophagy, and accumulation of dysfunctional mitochondria in the muscle when they were fed with a high-fat diet (HFD). These animals also have exacerbated body weight gain, increased intramyocellular lipid deposition, reduced energy expenditure, poor metabolic flexibility, and more insulin resistance. In contrast, consuming a BDNF mimetic (7,8-dihydroxyflavone) increased mitochondrial content, and enhanced mitofission and mitophagy in the skeletal muscles. Hence, BDNF is an essential myokine to maintain mitochondrial quality and function, and its repression in obesity might contribute to impaired metabolism.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13644
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Ahuja, P,Ng, CF,Pang, BPS,et al. Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice[J]. AUTOPHAGY,2022,18(6):1367-1384.
APA	Ahuja, P.,Ng, CF.,Pang, BPS.,Chan, WS.,Tse, MCL.,...&Chan, CB.(2022).Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice.AUTOPHAGY,18(6),1367-1384.
MLA	Ahuja, P,et al."Muscle-generated BDNF (brain derived neurotrophic factor) maintains mitochondrial quality control in female mice".AUTOPHAGY 18.6(2022):1367-1384.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023041214.pdf（5068KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文