Transcriptome-wide Association Study Identifies Genetically Dysregulated Genes in Diabetic Neuropathy

	Transcriptome-wide Association Study Identifies Genetically Dysregulated Genes in Diabetic Neuropathy
	Lan, DF; Jiang, HY; Su, XY; Zhao, Y; Du, SC; Li, Y; Bi, R; Zhang, DF; Yang, QP
	2021
发表期刊	COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
ISSN	1386-2073
卷号	24 期号:2 页码:319-325
摘要	Background: Complications are the main cause of the disease burden of diabetes. Genes determining the development and progression of diabetic complications remain to be identified. Diabetic neuropathy is the most common and debilitating complication and mainly affects the nerves of legs and feet. In this study, we attempted to identify diabetic neuropathy-specific genes from reliable large-scale genome-wide association studies (GWASs) for diabetes perse. Methods: Taking advantage of publicly available data, we initially converted the GWAS signals to transcriptomic profiles in the tibial nerve using the functional summary-based imputation (FUSION) algorithm. The FUSION-derived genes were then checked to determine whether they were differentially expressed in the sciatic nerve of mouse models of diabetic neuropathy. The dysregulated genes identified in the sciatic nerve were explored in the blood of patients with diabetes. Results: We found that eleven out of 452 FUSION-derived genes were regulated by diabetes GWAS loci and were altered in the sciatic nerve of mouse models with early-stage neuropathy. Among the eleven genes, significant (P-value<0.05) expression alterations of HSD17B4, DHX32, MERTK, and SFXN4 could be detected in the blood of human patients. Conclusions: Our analyses identified genes with an effect in the sciatic nerve and provided the possibility of noninvasive early detection of diabetic neuropathy.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13646
专题	科研部门_复杂疾病表观遗传机制与模型(张登峰）昆明动物研究所
推荐引用方式 GB/T 7714	Lan, DF,Jiang, HY,Su, XY,et al. Transcriptome-wide Association Study Identifies Genetically Dysregulated Genes in Diabetic Neuropathy[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2021,24(2):319-325.
APA	Lan, DF.,Jiang, HY.,Su, XY.,Zhao, Y.,Du, SC.,...&Yang, QP.(2021).Transcriptome-wide Association Study Identifies Genetically Dysregulated Genes in Diabetic Neuropathy.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,24(2),319-325.
MLA	Lan, DF,et al."Transcriptome-wide Association Study Identifies Genetically Dysregulated Genes in Diabetic Neuropathy".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 24.2(2021):319-325.

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2023031401.pdf（5356KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文