The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process

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	The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process
	Wu, CI; Wang, HY; Ling, SP; Lu, XM
	2016
发表期刊	ANNUAL REVIEW OF GENETICS, VOL 50
ISSN	0066-4197
卷号	50 页码:347-369
摘要	Although tumorigenesis has been accepted as an evolutionary process (20, 102), many forces may operate differently in cancers than in organisms, as they evolve at vastly different time scales. Among such forces, natural selection, here defined as differential cellular proliferation among distinct somatic cell genotypes, is particularly interesting because its action might be thwarted in multicellular organisms (20, 29). In this review, selection is analyzed in two stages of cancer evolution: Stage I is the evolution between tumors and normal tissues, and Stage II is the evolution within tumors. The Cancer Genome Atlas (TCGA) data show a low degree of convergent evolution in Stage I, where genetic changes are not extensively shared among cases. An equally important, albeit much less highlighted, discovery using TCGA data is that there is almost no net selection in cancer evolution. Both positive and negative selection are evident but they neatly cancel each other out, rendering total selection ineffective in the absence of recombination. The efficacy of selection is even lower in Stage II, where neutral (non-Darwinian) evolution is increasingly supported by high-density sampling studies (81, 123). Because natural selection is not a strong deterministic force, cancers usually evolve divergently even in similar tissue environments.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13654
专题	个人在本单位外知识产出
推荐引用方式 GB/T 7714	Wu, CI,Wang, HY,Ling, SP,et al. The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process[J]. ANNUAL REVIEW OF GENETICS, VOL 50,2016,50:347-369.
APA	Wu, CI,Wang, HY,Ling, SP,&Lu, XM.(2016).The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process.ANNUAL REVIEW OF GENETICS, VOL 50,50,347-369.
MLA	Wu, CI,et al."The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process".ANNUAL REVIEW OF GENETICS, VOL 50 50(2016):347-369.

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2023041205.pdf（300KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文