Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis

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	Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis
	Luo, YT; Lu, XM; Xie, HH
	2014
发表期刊	BIOMED RESEARCH INTERNATIONAL
ISSN	2314-6133
卷号	2014
摘要	DNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats. The methylation of Alu elements is an important mechanism to suppress Alu transcription and subsequent retrotransposition. Decades of studies revealed that Alu methylation is highly dynamic during early development and aging. Recently, many environmental factors were shown to have a great impact on Alu methylation. In addition, aberrant Alu methylation has been documented to be an early event in many tumors and Alu methylation levels have been associated with tumor aggressiveness. The assessment of the Alu methylation has become an important approach for early diagnosis and/or prognosis of cancer. This review focuses on the dynamic Alu methylation during development, aging, and tumor genesis. The cause and consequence of Alu methylation changes will be discussed.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13660
专题	个人在本单位外知识产出
推荐引用方式 GB/T 7714	Luo, YT,Lu, XM,Xie, HH. Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis[J]. BIOMED RESEARCH INTERNATIONAL,2014,2014.
APA	Luo, YT,Lu, XM,&Xie, HH.(2014).Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis.BIOMED RESEARCH INTERNATIONAL,2014.
MLA	Luo, YT,et al."Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis".BIOMED RESEARCH INTERNATIONAL 2014(2014).

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2023041211.pdf（802KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文