Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

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	Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data
	Tao, Y; Ruan, J; Yeh, SH; Lu, XM; Wang, Y; Zhai, WW; Cai, J; Ling, SP; Gong, Q; Chong, ZC; Qu, ZZ; Li, QQ; Liu, J; Yang, J; Zheng, CH; Zeng, CQ; Wang, HY; Zhang, J; Wang, SH; Hao, LT; Dong, LL; Li, WJ; Sun, M; Zou, W; Yu, CX; Li, CH; Liu, GJ; Jiang, L; Xu, J; Huang, HW; Li, CY; Mi, SL; Zhang, B; Chen, BX; Zhao, WM; Hu, SN; Zhuang, SM; Shen, Y; Shi, SH; Brown, C; White, KP; Chen, DS; Chen, PJ; Wu, CI
	2011
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	108 期号:29 页码:12042-12047
摘要	We present the analysis of the evolution of tumors in a case of hepatocellular carcinoma. This case is particularly informative about cancer growth dynamics and the underlying driving mutations. We sampled nine different sections from three tumors and seven more sections from the adjacent nontumor tissues. Selected sections were subjected to exon as well as whole-genome sequencing. Putative somatic mutations were then individually validated across all 9 tumor and 7 nontumor sections. Among the mutations validated, 24 were amino acid changes; in addition, 22 large indels/copy number variants (>1 Mb) were detected. These somatic mutations define four evolutionary lineages among tumor cells. Separate evolution and expansion of these lineages were recent and rapid, each apparently having only one lineage-specific protein-coding mutation. Hence, by using a cell-population genetic definition, this approach identified three coding changes (CCNG1, P62, and an indel/fusion gene) as tumor driver mutations. These three mutations, affecting cell cycle control and apoptosis, are functionally distinct from mutations that accumulated earlier, many of which are involved in inflammation/immunity or cell anchoring. These distinct functions of mutations at different stages may reflect the genetic interactions underlying tumor growth.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13663
专题	个人在本单位外知识产出
推荐引用方式 GB/T 7714	Tao, Y,Ruan, J,Yeh, SH,et al. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2011,108(29):12042-12047.
APA	Tao, Y.,Ruan, J.,Yeh, SH.,Lu, XM.,Wang, Y.,...&Wu, CI.(2011).Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,108(29),12042-12047.
MLA	Tao, Y,et al."Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 108.29(2011):12042-12047.

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2023041214.pdf（382KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文