Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS

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	Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS
	Wu, J; Yeung, SCJ; Liu, SC; Qdaisat, A; Jiang, DW; Liu, WL; Cheng, Z; Liu, WJ; Wang, HX; Li, L; Zhou, ZM; Liu, R; Yang, CY; Chen, CS; Yang, RX
	2021
发表期刊	SIGNAL TRANSDUCTION AND TARGETED THERAPY
ISSN	2095-9907
卷号	6 期号:1
摘要	Weight loss and cachexia are common problems in colorectal cancer patients; thus, parenteral and enteral nutrition support play important roles in cancer care. However, the impact of nonessential amino acid components of nutritional intake on cancer progression has not been fully studied. In this study, we discovered that gastrointestinal cancer patients who received cysteine as part of the parenteral nutrition had shorter overall survival (P < 0.001) than those who did not. Cystine indeed robustly promotes colon cancer cell growth in vitro and in immunodeficient mice, predominately by inhibiting SESN2 transcription via the GCN2-ATF4 axis, resulting in mTORC1 activation. mTORC1 inhibitors Rapamycin and Everolimus block cystine-induced cancer cell proliferation. In addition, cystine confers resistance to oxaliplatin and irinotecan chemotherapy by quenching chemotherapy-induced reactive oxygen species via synthesizing glutathione. We demonstrated that dietary deprivation of cystine suppressed colon cancer xenograft growth without weight loss in mice and boosted the antitumor effect of oxaliplatin. These findings indicate that cyst(e)ine, as part of supplemental nutrition, plays an important role in colorectal cancer and manipulation of cyst(e)ine content in nutritional formulations may optimize colorectal cancer patient survival.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13668
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Wu, J,Yeung, SCJ,Liu, SC,et al. Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2021,6(1).
APA	Wu, J.,Yeung, SCJ.,Liu, SC.,Qdaisat, A.,Jiang, DW.,...&Yang, RX.(2021).Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS.SIGNAL TRANSDUCTION AND TARGETED THERAPY,6(1).
MLA	Wu, J,et al."Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS".SIGNAL TRANSDUCTION AND TARGETED THERAPY 6.1(2021).

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2023032908.pdf（5246KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文