STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression

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	STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression
	Liu, R; Yang, GX; Bao, M; Zhou, ZM; Mao, XY; Liu, WJ; Jiang, XY; Zhu, D; Ren, XL; Huang, J; Chen, CS
	2022
发表期刊	ONCOGENE
ISSN	0950-9232
卷号	41 期号:16 页码:2265-2274
摘要	Dual-specificity mitogen-activated protein kinase phosphatase-1 (MKP-1/DUSP1/CL-100) has been documented to promote breast cancer cell survival and chemoresistance. MKP-1 is an unstable protein that is ubiquitinated and degraded via the ubiquitin-proteasome system. However, it is not clear how MKP-1 protein stability is regulated in breast cancer. In this study, we performed a genome-wide siRNA library screen of deubiquitinases (DUBs) and identified STAMBPL1 as an MKP-1 DUB in breast cancer cells. STAMBPL1 interacts with MKP-1 and stabilizes MKP-1 via deubiquitination. Both STAMBPL1 and MKP-1 depletion sensitize breast cancer cells to cisplatin in vitro and in vivo, and ectopic overexpression of MKP-1 partially rescues STAMBPL1 depletion-induced cisplatin sensitivity. Furthermore, STAMBPL1 and MKP-1 depletion increased breast cancer sensitivity to cisplatin by increasing the phosphorylation and activation of c-Jun N-terminal protein kinase (JNK). Collectively, our findings not only identify STAMBPL1 as an MKP-1 DUB but also reveal a critical mechanism that regulates MKP-1 expression in breast cancer. Our findings indicate that the STAMBPL1/MKP-1 axis represents a potential therapeutic target in breast cancer.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13674
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Liu, R,Yang, GX,Bao, M,et al. STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression[J]. ONCOGENE,2022,41(16):2265-2274.
APA	Liu, R.,Yang, GX.,Bao, M.,Zhou, ZM.,Mao, XY.,...&Chen, CS.(2022).STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression.ONCOGENE,41(16),2265-2274.
MLA	Liu, R,et al."STAMBPL1 promotes breast cancer cell resistance to cisplatin partially by stabilizing MKP-1 expression".ONCOGENE 41.16(2022):2265-2274.

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