The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China
	Li, Z; Zhang, J; Zou, W; Xu, Q; Li, SY; Wu, J; Zhu, L; Zhang, YJ; Xu, L; Zhang, Y; Luo, QS; Nie, JY; Li, XX; Zou, TN; Chen, CS
	2021
发表期刊	PLOS ONE
ISSN	1932-6203
卷号	16 期号:7
摘要	Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) subtypes is not fully understood. In this study, the MTHFR C677T polymorphism was genotyped in 490 individuals with or without BC from southwestern China. Analysis of the association between the MTHFR C677T polymorphism and BC revealed that there was a significant association between the MTHFR C677T polymorphism and triple-negative breast cancer (TNBC) (OR = 2.83, 95% CI: 1.12-9.51, P = 0.0401). Furthermore, the MTHFR C677T polymorphism can also serve as a protective factor in luminal A breast cancer (OR = 0.57, 95% CI: 0.34-0.94, P = 0.0258). Evaluation of the association between the MTHFR C677T polymorphism and clinical characteristics indicated that people who suffered from hypertension had an increased risk for BC (OR = 2.27; 95% CI: 1.08-4.6; P = 0.0264), especially TNBC (OR = 215.38; 95% CI: 2.45-84430.3; P = 0.0317). Our results suggest that the MTHFR C677T polymorphism is significantly associated with susceptibility to luminal B breast cancer and TNBC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13679
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Li, Z,Zhang, J,Zou, W,et al. The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China[J]. PLOS ONE,2021,16(7).
APA	Li, Z.,Zhang, J.,Zou, W.,Xu, Q.,Li, SY.,...&Chen, CS.(2021).The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.PLOS ONE,16(7).
MLA	Li, Z,et al."The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China".PLOS ONE 16.7(2021).

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