A feedforward circuit between KLF5 and lncRNA KPRT4 contributes to basal-like breast cancer

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	A feedforward circuit between KLF5 and lncRNA KPRT4 contributes to basal-like breast cancer
	Du, GS; Sun, J; Li, Z; Zhang, Q; Liu, WJ; Yang, CY; Zhao, P; Wang, XY; Yin, QY; Luo, Y; Song, JH; Wen, Y; Wang, HX; Chen, CH; Hu, GS; Zhou, ZM; Mao, XY; Liu, W; Liu, ZZ; Jiang, DW; Chen, CS
	2022
发表期刊	CANCER LETTERS
ISSN	0304-3835
卷号	534
摘要	Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer with a poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in human cancers. Kruppel-like Factor 5 (KLF5) is a key oncogenic transcription factor in BLBC. However, the underlying mechanism of mutual regulation between KLF5 and lncRNA remains largely unknown. Here, we demonstrate that lncRNA KPRT4 promotes BLBC cell proliferation in vitro and in vivo. Mechanistically, KLF5 directly binds to the promoter of KPRT4 to promote KPRT4 transcription. Reciprocally, KPRT4 recruits the YB-1 transcription factor to the KLF5 promoter by interacting with YB-1 at its 5 ' domain and forming an RNA-DNA-DNA triplex structure at its 3 ' domain, resulting in enhanced transcription of KLF5 and ultimately establishing a feedforward circuit to promote cell proliferation. Moreover, the antisense oligonucleotide (ASO)-based therapy targeting KPRT4 substantially attenuated tumor growth in vivo. Clinically, the expression levels of YB-1, KLF5 and KPRT4 are positively correlated in clinical breast specimens. Together, our data suggest that KPRT4 is a major molecule for BLBC progression and that the feedforward circuit between KLF5 and KPRT4 may represent a potential therapeutic target in BLBC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13689
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Du, GS,Sun, J,Li, Z,et al. A feedforward circuit between KLF5 and lncRNA KPRT4 contributes to basal-like breast cancer[J]. CANCER LETTERS,2022,534.
APA	Du, GS.,Sun, J.,Li, Z.,Zhang, Q.,Liu, WJ.,...&Chen, CS.(2022).A feedforward circuit between KLF5 and lncRNA KPRT4 contributes to basal-like breast cancer.CANCER LETTERS,534.
MLA	Du, GS,et al."A feedforward circuit between KLF5 and lncRNA KPRT4 contributes to basal-like breast cancer".CANCER LETTERS 534(2022).

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