| Extracellular Matrix-Related Six-lncRNA Signature as a Novel Prognostic Biomarker for Bladder Cancer |
| Qing, LL; Gu, P; Liu, MS; Shen, JH; Liu, XD; Guang, RY; Ke, KB; Huang, Z; Lee, WH; Zhao, H
|
| 2020
|
| 发表期刊 | ONCOTARGETS AND THERAPY
 |
| ISSN | 1178-6930
|
| 卷号 | 13页码:12521-12538 |
| 摘要 | Introduction: Bladder cancer (BC) is the fourth-commones cancer and the sixth-leading cause of cancer-related death among men. However, a lack of reliable biomarkers remains a problem forprognosis and treatment of BC. lncRNAs have been shown to play important roles in various cancers, and have emerged as promising biomarkers for cancer prognosis and treatment. Methods: In this study, using univariate and multivariate Cox regression analysis, we examined the differential expression profiles of 1,651 lncRNAs in the TCGA BLCA cohort and created a prognostic gene signature composed of six lncRNAs (for SNHG12, MAFG-DT, ASMTL-AS1, LINC02321, LINC01322, and LINC00922), designed the SMALLL signature. Results: The SMALLL signature displayed significant prognostic power for overall survival for BC patients in multiple cohorts. Gene Ontology analysis showed that genes coexpressed with the SMALLL signature were associated with the extracellular matrix network, and immune cell-infiltration analysis showed that activated naive B cells, regulatory T cells, M0 macrophages, eosinophils, resting memory CD4 T cells and resting NK cells were significantly different in highand low-risk groups. We also confirmed differential expression of the lncRNAs of the SMALLL signature in BC tissue and paracancer normal tissue by qRT-PCR analysis. Cell-invasion and-migration experiments showed that MAFG-AS1, ASMTL-AS1, LINC02321, and LINC00922 significantly affected cell invasion and migration. Conclusion: Our study revealed that the lncRNA signature is an important predictive factor of prognosis and provides a promising biomarker for BC. |
| 收录类别 | sci
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13701
|
| 专题 | 遗传资源与进化国家重点实验室_保护遗传学(细胞库)
|
推荐引用方式
GB/T 7714 |
Qing, LL,Gu, P,Liu, MS,et al. Extracellular Matrix-Related Six-lncRNA Signature as a Novel Prognostic Biomarker for Bladder Cancer[J]. ONCOTARGETS AND THERAPY,2020,13:12521-12538.
|
| APA |
Qing, LL.,Gu, P.,Liu, MS.,Shen, JH.,Liu, XD.,...&Zhao, H.(2020).Extracellular Matrix-Related Six-lncRNA Signature as a Novel Prognostic Biomarker for Bladder Cancer.ONCOTARGETS AND THERAPY,13,12521-12538.
|
| MLA |
Qing, LL,et al."Extracellular Matrix-Related Six-lncRNA Signature as a Novel Prognostic Biomarker for Bladder Cancer".ONCOTARGETS AND THERAPY 13(2020):12521-12538.
|
修改评论