| Clinical significance of EPHX2 deregulation in prostate cancer |
| Liu, MS; Zhao, H; Xu, CX; Xie, PB; Wang, W; Yang, YY; Lee, WH; Jin, Y; Zhou, HQ
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| 2021
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| 发表期刊 | ASIAN JOURNAL OF ANDROLOGY
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| ISSN | 1008-682X
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| 卷号 | 23期号:1页码:109-+ |
| 摘要 | The arachidonic acid (AA) metabolic pathway participates in various physiological processes as well as in the development of malignancies. We analyzed genomic alterations in AA metabolic enzymes in the Cancer Genome Atlas (TCGA) prostate cancer (PCa) dataset and found that the gene encoding soluble epoxide hydrolase (EPHX2) is frequently deleted in PCa. EPHX2 mRNA and protein expression in PCa was examined in multiple datasets by differential gene expression analysis and in a tissue microarray by immunohistochemistry. The expression data were analyzed in conjunction with clinicopathological variables. Both the mRNA and protein expression levels of EPHX2 were significantly decreased in tumors compared with normal prostate tissues and were inversely correlated with the Gleason grade and disease-free survival time. Furthermore, EPHX2 mRNA expression was significantly decreased in metastatic and recurrent PCa compared with localized and primary PCa, respectively. In addition, EPHX2 protein expression correlated negatively with Ki67 expression. In conclusion, EPHX2 deregulation is significantly correlated with the clinical characteristics of PCa progression and may serve as a prognostic marker for PCa. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13708
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| 专题 | 遗传资源与进化国家重点实验室_保护遗传学(细胞库)
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推荐引用方式
GB/T 7714 |
Liu, MS,Zhao, H,Xu, CX,et al. Clinical significance of EPHX2 deregulation in prostate cancer[J]. ASIAN JOURNAL OF ANDROLOGY,2021,23(1):109-+.
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| APA |
Liu, MS.,Zhao, H.,Xu, CX.,Xie, PB.,Wang, W.,...&Zhou, HQ.(2021).Clinical significance of EPHX2 deregulation in prostate cancer.ASIAN JOURNAL OF ANDROLOGY,23(1),109-+.
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| MLA |
Liu, MS,et al."Clinical significance of EPHX2 deregulation in prostate cancer".ASIAN JOURNAL OF ANDROLOGY 23.1(2021):109-+.
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