Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica

KIZ OpenIR > 遗传资源与进化国家重点实验室 > 保护遗传学(细胞库)

	Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica
	Liu, ZC; Liang, JY; Lan, XQ; Li, T; Zhang, JR; Zhao, F; Li, G; Chen, PY; Zhang, Y; Lee, WH; Zhao, F
	2020
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	41 期号:2 页码:138-+
摘要	As the oldest venomous animals, centipedes use their venom as a weapon to attack prey and for protection. Centipede venom, which contains many bioactive and pharmacologically active compounds, has been used for centuries in Chinese medicine, as shown by ancient records. Based on comparative analysis, we revealed the diversity of and differences in centipede toxin-like molecules between Scolopendra mojiangica, a substitute pharmaceutical material used in China, and S. subspinipes mutilans. More than 6 000 peptides isolated from the venom were identified by electrospray ionization-tandem mass spectrometry (ESI-MS/MS) and inferred from the transcriptome. As a result, in the proteome of S. mojiangica, 246 unique proteins were identified: one in five were toxin-like proteins or putative toxins with unknown function, accounting for a lower percentage of total proteins than that in S. mutilans. Transcriptome mining identified approximately 10 times more toxin-like proteins, which can characterize the precursor structures of mature toxinlike peptides. However, the constitution and quantity of the toxin transcripts in these two centipedes were similar. In toxicity assays, the crude venom showed strong insecticidal and hemolytic activity. These findings highlight the extensive diversity of toxin-like proteins in S. mojiangica and provide a new foundation for the medical-pharmaceutical use of centipede toxin-like proteins.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13709
专题	遗传资源与进化国家重点实验室_保护遗传学(细胞库)
推荐引用方式 GB/T 7714	Liu, ZC,Liang, JY,Lan, XQ,et al. Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica[J]. ZOOLOGICAL RESEARCH,2020,41(2):138-+.
APA	Liu, ZC.,Liang, JY.,Lan, XQ.,Li, T.,Zhang, JR.,...&Zhao, F.(2020).Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica.ZOOLOGICAL RESEARCH,41(2),138-+.
MLA	Liu, ZC,et al."Comparative analysis of diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica".ZOOLOGICAL RESEARCH 41.2(2020):138-+.

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