Osteoking improves OP rat by enhancing HSP90-beta expression

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	Osteoking improves OP rat by enhancing HSP90-beta expression
	Sun, Y; Chen, R; Zhu, D; Shen, ZQ; Zhao, HB; Lee, WH
	2020
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN	1107-3756
卷号	45 期号:5 页码:1543-1553
摘要	Osteoporosis (OP) is a chronic bone disease that affects individuals worldwide. Osteoporosis is primarily asymptomatic, and patients with OP suffer from pain, inconvenience, economic pressure and osteoporotic fracture (OPF). Osteoking, a Traditional Chinese Medicine compound that originates from the Yi ethnic group, has been used for a number of years to treat fractures. In our previous study, osteoking exhibited therapeutic effects on rats with OPF by promoting calcium deposition. Based on bioinformatics and network pharmacology analyses of a component-target-disease database, heat shock protein HSP 90-beta (HSP90-beta), also known as HSP90-beta, was identified to be a key target of osteoking in OP. High HSP90-beta expression levels were observed in osteoporotic rats and rat bone mesenchymal stem cells (rBMSCs) following osteoking treatment. After 12 weeks of administration in vivo, there was increased bone mineral density (BMD) (P<0.05), increased bone alkaline phosphatase (P<0.05), and improved bone microstructure in the osteoking group compared with those of the negative control group. In vitro, increased calcium deposition in rBMSCs was observed after 4 weeks of osteoking treatment. These results suggest that the mechanisms of osteoking are closely associated with HSP90-beta and activate the bone morphogenetic protein (BMP) signalling pathway, primarily through BMP-2. Osteoking treatment improves OP in rats by enhancing HSP90-beta expression.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13711
专题	遗传资源与进化国家重点实验室_保护遗传学(细胞库)
推荐引用方式 GB/T 7714	Sun, Y,Chen, R,Zhu, D,et al. Osteoking improves OP rat by enhancing HSP90-beta expression[J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2020,45(5):1543-1553.
APA	Sun, Y,Chen, R,Zhu, D,Shen, ZQ,Zhao, HB,&Lee, WH.(2020).Osteoking improves OP rat by enhancing HSP90-beta expression.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,45(5),1543-1553.
MLA	Sun, Y,et al."Osteoking improves OP rat by enhancing HSP90-beta expression".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 45.5(2020):1543-1553.

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