Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function

KIZ OpenIR > 遗传资源与进化国家重点实验室 > 保护遗传学(细胞库)

	Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function
	Zhang, HJ; Qin, JW; Lan, XQ; Zeng, WR; Zhou, J; Huang, TE; Xiao, WL; Wang, QQ; Sun, SJ; Su, WT; Nie, WH; Yang, S; Yang, J; Gao, Q; Xiang, Y
	2022
发表期刊	BIOGERONTOLOGY
ISSN	1389-5729
卷号	23 期号:1 页码:115-128
摘要	Aging and aging-related disorders contribute to formidable socioeconomic and healthcare challenges. Several promising small molecules have been identified to target conserved genetic pathways delaying aging to extend lifespan and healthspan in many organisms. We previously found that extract from an edible and medicinal plant Chrysanthemum indicum L. (C. indicum L.) protect skin from UVB-induced photoaging, partially by reducing reactive oxygen species (ROS) generation. Thus, we hypothesized that C. indicum L. and its biological active compound may extend lifespan and health span in vivo. We find that both water and ethanol extracts from C. indicum L. extended lifespan of Caenorhabditis elegans, with better biological effect on life extending for ethanol extracts. As one of the major biological active compounds, handelin extended lifespan of C. elegans too. RNA-seq analysis revealed overall gene expression change of C. elegans post stimulation of handelin focus on several antioxidative proteins. Handelin significantly reduced ROS level and maintained the number and morphology of mitochondria. Moreover, handelin improveed many C. elegans behaviors related to healthspan, including increased pharyngeal pumping and body movement. Muscle fiber imaging analyses revealed that handelin maintains muscle architecture by stabilizing myofilaments. In conclusion, our present study finds a novel compound handelin, from C. indicum L., which bring about biologically beneficial effects by mild stress response, termed as hormetin, that can extend both lifespan and healthspan in vivo on C. elegans. Further study on mammal animal model of natural aging or sarcopenia will verify the potential clinical value of handelin.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13712
专题	遗传资源与进化国家重点实验室_保护遗传学(细胞库)
推荐引用方式 GB/T 7714	Zhang, HJ,Qin, JW,Lan, XQ,et al. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function[J]. BIOGERONTOLOGY,2022,23(1):115-128.
APA	Zhang, HJ.,Qin, JW.,Lan, XQ.,Zeng, WR.,Zhou, J.,...&Xiang, Y.(2022).Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function.BIOGERONTOLOGY,23(1),115-128.
MLA	Zhang, HJ,et al."Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function".BIOGERONTOLOGY 23.1(2022):115-128.

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