| Senolytic targets and new strategies for clearing senescent cells |
| Ge, MX; Hu, L; Ao, HS; Zi, MT; Kong, QP; He, YH
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| 2021
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| 发表期刊 | MECHANISMS OF AGEING AND DEVELOPMENT
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| ISSN | 0047-6374
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| 卷号 | 195 |
| 摘要 | Senescent cells (SCs) accumulate with age and cause various age-related diseases. Clearance of SCs by transgenic or pharmaceutical strategies has been demonstrated to delay aging, treat age-related diseases and extend healthspan. SCs are resistant to various stressors because they are protected from apoptosis by SC anti-apoptotic pathways (SCAPs). Targeting the proteins in the SCAPs with small molecules can selectively kill SCs, the effector proteins are called senolytic targets and the small molecules are called senolytics. Until now, a series of senolytic targets, such as BCL-XL, heat shock protein 90 (HSP90), Na+/K+ ATPase, bromodomain containing 4 (BRD4), and oxidation resistance 1 (OXR1) have been identified. However, current senolytics targeting these proteins still have some limitations in killing SCs in terms of safety, specificity and broad-spectrum activity. To overcome the challenges, some new strategies, such as proteolysis-targeting chimera (PROTAC) technology, chimeric antigen receptor (CAR) T cells, and ?-galactosidase-modified prodrugs, were developed to clear SCs and shown to have promising therapeutic potential. Here we review the significance of SCs in aging and age-related diseases, summarize the known senolytic targets and highlight the emerging new strategies for clearing SCs. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13715
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| 专题 | 科研部门_分子人类学（孔庆鹏）
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推荐引用方式
GB/T 7714 |
Ge, MX,Hu, L,Ao, HS,et al. Senolytic targets and new strategies for clearing senescent cells[J]. MECHANISMS OF AGEING AND DEVELOPMENT,2021,195.
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| APA |
Ge, MX,Hu, L,Ao, HS,Zi, MT,Kong, QP,&He, YH.(2021).Senolytic targets and new strategies for clearing senescent cells.MECHANISMS OF AGEING AND DEVELOPMENT,195.
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| MLA |
Ge, MX,et al."Senolytic targets and new strategies for clearing senescent cells".MECHANISMS OF AGEING AND DEVELOPMENT 195(2021).
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