| ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity |
| Xiao, FH; Yu, Q ; Deng, ZL; Yang, K; Ye, YS; Ge, MX; Yan, DJ; Wang, HT; Chen, XQ; Yang, LQ; Yang, BY; Lin, R; Zhang, W; Yang, XL; Dong, L; He, YH; Zhou, JM; Cai, WW; Li, J; Kong, QP
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| 2022
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| 发表期刊 | SCIENCE ADVANCES
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| ISSN | 2375-2548
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| 卷号 | 8期号:17 |
| 摘要 | Adaptation to reduced energy production during aging is a fundamental issue for maintaining healthspan or prolonging life span. Currently, however, the underlying mechanism in long-lived people remains poorly understood. Here, we analyzed transcriptomes of 193 long-lived individuals (Ws) and 86 spouses of their children from two independent Chinese longevity cohorts and found that the ribosome pathway was significantly down-regulated in LLIs. We found that the down-regulation is likely controlled by ETS1(ETS proto-oncogene 1), a transcription factor down-regulated in LLIs and positively coexpressed with most ribosomal protein genes (RPGs). Functional assays showed that ETS1 can bind to RPG promoters, while ETS1 knockdown reduces RPG expression and alleviates cellular senescence in human dermal fibroblast (HDF) and embryonic lung fibroblast (IMR-90) cells. As protein synthesis/turnover in ribosomes is an energy-intensive cellular process, the decline in ribosomal biogenesis governed by ETS1 in certain female LLIs may serve as an alternative mechanism to achieve energy-saving and healthy aging. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13720
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| 专题 | 科研部门_分子人类学（孔庆鹏）
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推荐引用方式
GB/T 7714 |
Xiao, FH,Yu, Q,Deng, ZL,et al. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity[J]. SCIENCE ADVANCES,2022,8(17).
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| APA |
Xiao, FH.,Yu, Q.,Deng, ZL.,Yang, K.,Ye, YS.,...&Kong, QP.(2022).ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity.SCIENCE ADVANCES,8(17).
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| MLA |
Xiao, FH,et al."ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity".SCIENCE ADVANCES 8.17(2022).
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