Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity

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	Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity
	Ge, MX; Jiang, JJ; Yang, LQ; Yang, XL; He, YH; Li, GH; Kong, QP
	2022
发表期刊	GENES
卷号	13 期号:5
摘要	Deep RNA sequencing of 164 blood samples collected from long-lived families was performed to investigate the expression patterns of circular RNAs (circRNAs). Unlike that observed in previous studies, circRNA expression in long-lived elderly individuals (98.3 +/- 3.4 year) did not exhibit an age-accumulating pattern. Based on weighted circRNA co-expression network analysis, we found that longevous elders specifically gained eight but lost seven conserved circRNA-circRNA co-expression modules (c-CCMs) compared with normal elder controls (spouses of offspring of long-lived individuals, age = 59.3 +/- 5.8 year). Further analysis showed that these modules were associated with healthy aging-related pathways. These results together suggest an important role of circRNAs in regulating human lifespan extension.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13721
专题	科研部门_分子人类学（孔庆鹏）
推荐引用方式 GB/T 7714	Ge, MX,Jiang, JJ,Yang, LQ,et al. Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity[J]. GENES,2022,13(5).
APA	Ge, MX.,Jiang, JJ.,Yang, LQ.,Yang, XL.,He, YH.,...&Kong, QP.(2022).Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity.GENES,13(5).
MLA	Ge, MX,et al."Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity".GENES 13.5(2022).

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2023032915.pdf（2474KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文