| Mechanism of Thymus Rejuvenation in Elderly Macaques | |
| Wang, YY; Chang, L; Zhu, GH; Li, GH; Kong, QP; Lv, LB; Wang, Q; Tian, C; Li, Y; Zhu, XQ; Pan, XH | |
| 2022 | |
| 发表期刊 | REJUVENATION RESEARCH
 |
| ISSN | 1549-1684 |
| 卷号 | 25期号:5页码:223-232 |
| 摘要 | Senile thymus atrophy is an important factor leading to decreased immune function. Repairing the atrophic thymus tissue structure, rebuilding immune function, and replenishing the number of exogenous stem cells may be ideal methods. In this study, bone marrow mesenchymal stem cells were intravenously infused into elderly macaques. We found that thymus volume was substantially increased, some thymus tissue regeneration was observed, the degree of thymus tissue fibrosis decreased, collagen fiber deposition decreased, cortical and medulla structures emerged gradually, the number of apoptotic cells decreased significantly, and the expression of apoptosis-related proteins decreased. For the effects of stem cell therapy on aging-related genes, we performed transcriptomic analysis of thymus tissue. The results show the expression pattern of the tissue transcriptome tended to be similar to the thymus expression pattern in young macaques compared with the elderly group, reverse aging-related proteins. Based on the results, it is suggested that stem cell therapy is an ideal method to prevent or reverse the aging of the thymus. |
| 收录类别 | sci |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13726 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Wang, YY,Chang, L,Zhu, GH,et al. Mechanism of Thymus Rejuvenation in Elderly Macaques[J]. REJUVENATION RESEARCH,2022,25(5):223-232. |
| APA | Wang, YY.,Chang, L.,Zhu, GH.,Li, GH.,Kong, QP.,...&Pan, XH.(2022).Mechanism of Thymus Rejuvenation in Elderly Macaques.REJUVENATION RESEARCH,25(5),223-232. |
| MLA | Wang, YY,et al."Mechanism of Thymus Rejuvenation in Elderly Macaques".REJUVENATION RESEARCH 25.5(2022):223-232. |
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| 2023032922.pdf（1165KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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