An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data

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	An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
	Zhang, CY; Xiao, X; Zhang, ZH; Hu, ZH; Li, M
	2022
发表期刊	MOLECULAR PSYCHIATRY
ISSN	1359-4184
卷号	27 期号:1 页码:95-112
摘要	Alternative splicing of schizophrenia risk genes, such as DRD2, GRM3, and DISC1, has been extensively described. Nevertheless, the alternative splicing characteristics of the growing number of schizophrenia risk genes identified through genetic analyses remain relatively opaque. Recently, transcriptomic analyses in human brains based on short-read RNA-sequencing have discovered many local splicing events (e.g., exon skipping junctions) associated with genetic risk of schizophrenia, and further molecular characterizations have identified novel spliced isoforms, such as AS3MT(d2d3) and ZNF804A(E3E4). In addition, long-read sequencing analyses of schizophrenia risk genes (e.g., CACNA1C and NRXN1) have revealed multiple previously unannotated brain-abundant isoforms with therapeutic potentials, and functional analyses of KCNH2-3.1 and Ube3a1 have provided examples for investigating such spliced isoforms in vitro and in vivo. These findings suggest that alternative splicing may be an essential molecular mechanism underlying genetic risk of schizophrenia, however, the incomplete annotations of human brain transcriptomes might have limited our understanding of schizophrenia pathogenesis, and further efforts to elucidate these transcriptional characteristics are urgently needed to gain insights into the illness-correlated brain physiology and pathology as well as to translate genetic discoveries into novel therapeutic targets.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13733
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Zhang, CY,Xiao, X,Zhang, ZH,et al. An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data[J]. MOLECULAR PSYCHIATRY,2022,27(1):95-112.
APA	Zhang, CY,Xiao, X,Zhang, ZH,Hu, ZH,&Li, M.(2022).An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data.MOLECULAR PSYCHIATRY,27(1),95-112.
MLA	Zhang, CY,et al."An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data".MOLECULAR PSYCHIATRY 27.1(2022):95-112.

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